The X Millas del Guadiana is an 18-kilometer road race connecting Ayamonte (Huelva, Andalusia) with the Portuguese towns of Castro Marim and Vila Real de Santo António. This cross-border athletic event takes place entirely on asphalt and symbolizes the connection between the Algarve region and Andalusia. The race is characterized by its route that crosses the Spanish-Portuguese border, offering a unique experience to participants. The organization is supported by the Provincial Council of Huelva and sports commissions from both countries.